Citation: Tai-De Li, Peter Bieling, Julian Weichsel, R Dyche Mullins, Daniel A Fletcher (2022).
Link: Zotero
Summary
- Key finding:
- Method:
- Limitations:
- Notes in my words:
Relevance to my research
- Directly relevant
- Establishes the relationship between capping rate and the load force on the growing actin network
- The Brownian ratchet mechanism of capping of free barbed ends is implemented in our model
- Background
- Methods
Quotes / Figures
We have demonstrated that compressive forces increase the density of growing filament ends at the leading edge of a branched actin network by decreasing the (per-filament) rate of capping, and not by increasing the overall rate of nucleation.
The binding of capping protein to the free barbed end of an actin filament is a bi-molecular interaction, whose rate depends on the concentration of capping protein and the rate constant for filament capping, that is . All our results are consistent with the idea that force decreases the capping rate constant, , without changing the local concentration of capping protein.